Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 11 0.002 0.249 0.12 0.074
biological_process el 11 0.583 0.912 0.771 0.117
biological_process ka 11 0.001 0.213 0.109 0.067
biological_process rf 11 0.002 0.249 0.12 0.074
cellular_component ct 11 0.001 0.541 0.177 0.148
cellular_component el 11 0.065 0.96 0.467 0.311
cellular_component ka 11 0.0 0.544 0.169 0.148
cellular_component rf 11 0.001 0.541 0.177 0.148
disease ct 4 0.033 0.675 0.196 0.277
disease el 4 0.271 0.738 0.555 0.173
disease ka 4 0.004 0.636 0.168 0.271
disease rf 4 0.033 0.675 0.196 0.277
genetic_interaction ct 9 0.0 0.989 0.607 0.355
genetic_interaction el 9 0.0 0.991 0.605 0.358
genetic_interaction ka 9 0.0 0.226 0.159 0.087
genetic_interaction rf 9 0.0 0.989 0.607 0.355
molecular_function ct 11 0.004 0.829 0.322 0.28
molecular_function el 11 0.077 0.95 0.535 0.334
molecular_function ka 11 0.001 0.831 0.333 0.279
molecular_function rf 11 0.004 0.829 0.322 0.28
pathway ct 11 0.001 0.793 0.396 0.299
pathway el 11 0.0 0.681 0.28 0.256
pathway ka 11 0.0 0.164 0.022 0.046
pathway rf 11 0.0 0.571 0.253 0.204
phenotype ct 4 0.006 0.641 0.3 0.293
phenotype el 4 0.077 0.417 0.254 0.132
phenotype ka 4 0.005 0.682 0.314 0.31
phenotype rf 4 0.006 0.641 0.301 0.294
protein_interaction ct 11 0.002 0.219 0.111 0.093
protein_interaction el 11 0.002 0.174 0.071 0.067
protein_interaction ka 11 0.0 0.038 0.008 0.011
protein_interaction rf 11 0.002 0.214 0.104 0.089

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 11 0.001 0.776 0.326 0.303
integration_mean_by_presence el 11 0.164 0.658 0.372 0.145
integration_mean_by_presence ka 11 0.0 0.685 0.268 0.261
integration_mean_by_presence rf 11 0.0 0.816 0.249 0.28
mean ct 11 0.0 0.74 0.291 0.288
mean el 11 0.0 0.497 0.153 0.137
mean ka 11 0.0 0.347 0.134 0.137
mean rf 11 0.0 0.339 0.115 0.121

CDF plots of non integrated kernels

CDF plots of integrated kernels